Cavaliers vs 76ers Prediction, Odds & Pick (Oct 22, 2026)

SetupMatchup and context

The Cavaliers and the 76ers meet at Xfinity Mobile Arena for a regular-season game. Tip-off is set for 7:00 PM EDT, which is 07:00 on Oct 23 in UTC+8.

Records: Cavaliers 0-0, 76ers 1-0.

Model vs marketPrice check

The model has the Cavaliers at 42.5%. Polymarket priced them at 41.5¢ at the mid, with the best ask at 42¢. That's +1.0¢ of edge at the mid and +0.5¢ at the ask, and the ask is the number that matters because it's what you would actually pay.

The other side, the 76ers, traded at 58.5¢ against a model number of 57.5%.

Liquidity on the market was about $312K when we pulled the book (Oct 22, 2026, 21:22 UTC+8). NBA leans need at least 2.5¢ of edge at the ask.

MatchupThe ratings behind the number

The model runs on 2026-27 team ratings. In that data, the Cavaliers went 0-0 with a +3.4 net rating (117.1 offense, 113.6 defense) and a 0-0 last-10 mark; the 76ers went 1-0 with a +0.1 net rating (112.9 offense, 112.8 defense) and a 1-0 last-10 mark.

The projected margin comes out to 76ers by 1.6, and that includes 3.5 points of home court.

None of that knows who is actually playing tonight. The NBA model is not lineup-aware.

BooksWhat the books say

Over at DraftKings it was PHI -3.5 with the total at 235.5. No-vig, the Cavaliers come out at 42.8%. ESPN's matchup predictor had the 76ers at 70.8% and the Cavaliers at 29.2%.

Model and sportsbooks land within a point or so of each other here.

AvailabilityAvailability report

On the Cavaliers side, ESPN listed Nae'Qwan Tomlin (back, out), Khalifa Diop (knee, out), and Jarrett Allen (knee, day-to-day).

ESPN's injury report for the 76ers: Ariel Hukporti (achilles, out), Dominick Barlow (back, out), Dean Wade (ankle, day-to-day), and Tacko Fall (quadriceps, out).

VerdictLean, pass, or context?

We passed. +0.5¢ of executable edge on the Cavaliers isn't enough (the bar is 2.5¢), so this one stays off the record.